Melissa did some directing for Jack of All Trades, and was a story editor for Heroes before becoming a writer. She has written at least two episodes of Kevin Hill. She has also written for Xena: Warrior Princess, The Huntress, Cleopatra 2525, and Jack of All Trades. Additionally, she was Robert Tapert's personal assistant on Hercules: The Legendary Journeys. Following Heroes, Melissa did story editing as well as episode writing for Ghost Whisperer.
- Melissa Blake and Joy Blake are sisters.
- Melissa Blake met her husband, Roberto Orci (Alias), while working on Hercules and Xena--he was a writer for the shows.